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Die Position
At Roche, we create transformative medicines to tackle some of the world's toughest unmet healthcare needs for patients. At CICoR, we aspire to serve patients by leveraging China's life science ecosystem to accelerate scientific innovation and develop breakthrough medicines. Together, we cultivate a culture defined by curiosity, responsibility, and humility—one where our talented people are empowered and inspired to deliver extraordinary, life-changing innovation at speed.
The mission of our biomarker team is to accelerate early-phase clinical development, through effective patient selection and enrichment, and generation and analysis of clinical biomarker data. These efforts enable proof-of-mechanism (PoM) demonstration and deeper disease understanding, supporting faster and more confident decision-making. In addition, we provide biomarker expertise to discovery projects to elucidate the molecular pathways that drive disease.
We are seeking a highly motivated individual to lead the biomarker team. In this role, you will strategize and deliver rigorous biomarker support across multiple disease areas—including Oncology, Immunology, Neurology, Cardiovascular& Metabolism, and Ophthalmology, etc.—to advance translational science in China. You will ensure strong contributions to programs in both early- and late-stage clinical development by collaborating with cross-functional teams in China and globally, as well as with key TAEs and CROs in China.
Roles and Responsibilities
- Lead and mentor a multidisciplinary team of biomarker experts while also serving as an hands-on individual contributor.
- Define and drive the China biomarker strategy for early and late-phase clinical development programs, including providing program-specific feasibility assessments and execution plans.
- Serve as the biomarker subject matter expert on clinical development project teams, advising on disease biology and biomarker science.
- Support the generation and review of critical clinical development documents (e.g., protocols, ICFs) to ensure alignment with biomarker strategies.
- Partner with global biomarker and project teams to lead the execution of biomarker studies, including data analysis, interpretation, and reporting.
- Integrate preclinical, clinical, and real-world data to guide indication selection and develop patient enrichment strategies to increase the probability of clinical success for CICoR programs.
- Design and lead forward and reverse translational research studies in collaboration with internal and external partners to support the preclinical and clinical portfolio.
- Stay abreast of novel biomarker modalities and technologies to drive the prioritization and harmonization of biomarker platforms across the portfolio.
- Lead biomarker assay outsourcing efforts, including overseeing assay development, transfer, validation, and execution at CROs for both non-clinical and clinical studies.
- Ensure data integrity through critical review and validation of CRO-generated results.
- Identify, select, and manage external vendors and institutional collaborators to ensure the timely delivery of high-quality data.
Qualification
- PhD or MD in a relevant scientific field (e.g., Molecular Biology, Cell Biology, Oncology, Immunology, etc.).
- Minimum of 5 years of pharmaceutical industry experience in Translational Medicine, Clinical Development, or Biology research, with a strong preference for candidates possessing a background in biomarker research or clinical biomarker development.
- Proven experience in E2E clinical drug development, including drafting relevant documents (e.g., protocols, ICFs) and a solid understanding of cross-functional interfaces such as Clinical Science, Clinical Pharmacology, Regulatory, Safety, Operations, and Biostatistics.
- Deep familiarity with the regulatory landscape and competitive environment in China.
- Extensive knowledge of state-of-the-art biomarker technologies, including immunoassays, NGS, IHC, FACS, PCR, and imaging-based modalities (MRI/DXA/PET).
- Demonstrated expertise in generating and interpreting data from diverse sample types to establish proof of biology, support dose selection, and develop patient enrichment strategies.
- Thrives in a dynamic, inclusive environment, taking full accountability for personal contributions and development.
- Resourceful and flexible problem-solver, capable of working collaboratively while ensuring cross-team alignment.
- Transparent and empathetic leader with strong coaching skills and a commitment to keeping teams informed and engaged.
- Strategic thinker with a holistic, ecosystem-oriented mindset, coupled with strong analytical abilities.
- Excellent communication and interpersonal skills in both English and Chinese, with the proven ability to influence stakeholders and drive consensus.
Wer wir sind
Eine gesündere Zukunft treibt uns zur Innovation an. Mehr als 100.000 Mitarbeiter weltweit arbeiten gemeinsam daran, wissenschaftliche Fortschritte zu erzielen und sicherzustellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und für zukünftige Generationen. Durch unser Engagement werden über 26 Millionen Menschen mit unseren Medikamenten behandelt und mehr als 30 Milliarden Tests mit unseren Diagnostik-Produkten durchgeführt. Wir ermutigen uns gegenseitig, neue Möglichkeiten zu erkunden, Kreativität zu fördern und hohe Ziele zu setzen, um lebensverändernde Gesundheitslösungen zu liefern.
Gemeinsam können wir eine gesündere Zukunft gestalten.
Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.
