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Senior Scientist-Peptide Synthesis

Boehringer Ingelheim Shanghai Pharmaceuticals Co., Ltd. -
上海市

立即申请

职位详情

2 天前

完整职位描述

About Human Pharmaceutical Business
With global presence, Boehringer Ingelheim has industry-leading expertise in medicine research and development. We are constantly developing the next generation of medical breakthroughs and successfully delivering innovations to meet the medical needs of the patients we serve in the following key areas of interest: cardiovascular, respiratory, metabolic diseases, immunology, oncology and central nervous system. In the future, we will accelerate the launch of more than 10 innovative medicines to meet the demand of Chinese patients.

Position Summary
This role focuses on late-stage peptide process development with an emphasis on process robustness, consistency, and cost efficiency. The successful candidate will drive process optimization from development through scale-up and commercialization, ensuring stable, reproducible, and economically viable manufacturing processes.

Key Responsibilities

Lead late-stage process development and optimization for peptide products, with a focus on SPPS processes
Improve process robustness, batch-to-batch consistency, and define proven acceptable ranges
Optimize raw material usage, cycle times, and process efficiency to reduce manufacturing cost
Identify and control critical process parameters (CPPs) and critical quality attributes (CQAs)
Support and lead technology transfer to pilot plant and commercial manufacturing sites
Collaborate with analytical, quality, and manufacturing teams to resolve scale-up issues
Conduct root cause analysis, deviation investigations, and continuous improvement (CI) initiatives
Develop platform approaches for peptide synthesis and purification
Prepare technical reports, process documentation, and regulatory support documents

Qualifications

Master's or Ph.D. in Chemistry, Pharmaceutical Sciences, or related field
3+ years of experience in peptide process development or optimization
Hands-on experience in process scale-up from lab to pilot or commercial manufacturing
Strong knowledge of solid-phase peptide synthesis (SPPS)
Proven experience in cost reduction and process efficiency improvement

Technical Skills

Deep understanding of peptide synthesis mechanisms and impurity control
Experience with analytical techniques such as HPLC and LC-MS
Familiarity with Design of Experiments (DoE) methodologies
Knowledge of purification techniques (Prep-HPLC, crystallization, membrane processes)
Understanding of GMP requirements for process development and scale-up

Core Competencies

Strong data analysis and problem-solving skills
Effective cross-functional communication and collaboration
Engineering mindset with focus on scalability, reproducibility, and cost
Results-driven with focus on quality and efficiency balance

Preferred Qualifications

Experience with commercial peptide or API manufacturing
Experience in process validation and regulatory submissions
Exposure to continuous manufacturing or automation technologies

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global pilot 个职位

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